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The manager how long does it take for nexium 24 to work At least 185 aquatic invaders have reached the Great Lakes, mostly in ballast water, experts say. Among the most notorious are zebra and quagga mussels, which have done untold millions of dollars in damage and spread all the way to California, clogging pipes at power and wastewater treatment plants. They’re also believed at least partly responsible for growth of harmful algae, die-offs of loons and other shore birds and declines of some types of fish.